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Pueraria
mirifica is
Thailand’s endemic species found mainly in the northern and
western part of Thailand and has local name as “White Kwao
Krua”. The Thai vine herbal plant is grown in association with
the moderate-size trees ranking from timber wood to bamboo in
the deciduous rain forest. The enlarge underground tuber
accumulate “phytoestrogens” comprising isoflavone. The compounds
that make Pueraria mirifica different from any other phytoestrogen-
containing plants in the Family Leguminosae are Miroestrol and
Deoxymiroestrol, which possess highest estrogenic activity among
the known phytoestrogens due to structural similarity to
estradiol. Miroestrol was actually the first compound isolated
from this plant by a group of German chemists in 1940, but the
plant had been mistakenly reported then as Butea superba. It was
later on classified as a new plant called Pueraria mirifica Airy
Shaw et Suvatabhandu. The isolation and identification of
deoxymiroestrol from the root of Pueraria mirifica has just been
reported in the February 2000 issue of the Journal of Natural
Products. The authors proposed that since deoxymiroestrol is
easily oxidized to miroestrol, deoxymiroestrol, not the
previously reported miroestrol, is more likely to be the actual
chemical constituent of Pueraria mirifica. However, it is very
likely that the two phytoestrogens coexist in the root of this
plant. AS shown below, the chemical structures of the two
compounds are very similar to that of estradiol, the main human
estrogen.
In addition to
miroestrol and deoxymiroestrol, Pueraria mirifica also contains
other chemicals that belong to isoflavone and coumestran groups
of phytoestrogens, e.g., Genistein, Daidzein, Daidzin,
Genistin,
and Coumestrol that are usually found in soybeans. (Table).
However, the estrogenic activity of Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones.
Table :
Chromene, Isoflavonoid and coumestran derivatives in Pueraria
mirifica
|
Chromene |
Isoflavones |
Isoflavone |
Coumestans glycosides |
|
Miroestrol |
Daidzein |
Daidzin |
Coumestrol |
|
Deoxymiroestrol |
Genistein |
Genistin
|
Mirificoumestan
|
| |
Kawakhurin |
Mirificin |
Mirificoumestan
glycol
|
| |
Kawakhurin hydrate |
Puerarin
|
Mirificoumestan hydrate |
| |
|
Puerarin-6"-
monoacetate
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The results from the studies of
researchers and acadamics shows
that
The results from the studies of researchers and acadamics shows
that the selected Pueraria mirifica cultivar
contains very high isoflavone contents and
showing high antimutagenic effects as well as high killing
effects to human mammary cancer cell line. Nowadays
nutritionists recommend the consumer to consume isoflavone
regularly for the purpose of cancer protection.
Miroestrol and
its derivatives are also
precious chemicals in the White Kwao Krua which promote
estrogenic and mammogenic effects to various tissues and organs
such as uterus, ovary and skin.
Soy which is used in Asia and throughout the world contains significantly
lower phytoestrogen content than pueraria mirifica. What makes pueraria
mirifica most unique is the two chromenes, miroestrol and its precursor
deoxymiroestrol. There is ample research suggesting phytoestrogens support
for cardiac health, breast health, prostate health, colon health, healthy
cholesterol and bone health.
  
  
The selected cultivar from our organic farming has been processed based on the
5 Gs;
1. Good Agricultural practice; our company exhibit a
huge plantation site for our own raw materials with
organic farming concepts.
2. Good Harvesting Practice; right harvesting is
strictly submitted to guarantee the best raw
material supply.
3. Good Laboratory Practice; quality control is
strictly under standard analysis of the raw
materials and final products.
4. Good
Clinical Practice; the products are continuously clinical testing from
researchers
and acadamics,
5. Good Manufacturing Practice; all products are
manufactured in GMP factories.
Most of
all, our R&D focus mainly on high efficacy and high safety
of all the products.
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